Wnt/ -Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra

Wnt/beta-catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.

In and evaginations of 2D cell sheets are major shape generating processes in animal development. They result from directed movement and intercalation of polarized cells associated with cell shape changes. Work on several bilaterian model organisms has emphasized the role of noncanonical Wnt signaling in cell polarization and movement. However, the molecular processes responsible for generating...

The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy

Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...

Noncanonical Wnt Signaling in Bone

The Wnt family of proteins plays essential roles conserved from flies to human in many developmental processes including cell fate specification, polarity, migration and proliferation. It has becoming increasingly clear that Wnt proteins activate multiple intracellular signaling cascades to achieve the diverse biological functions. One such cascade that has been most intensely studied to date i...

Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis

Wnt regulates bone formation through β-catenin-dependent canonical and -independent noncanonical signaling pathways. However, the cooperation that exists between the two signaling pathways during osteoblastogenesis remains to be elucidated. Here, we showed that the lack of Wnt5a in osteoblast-lineage cells impaired Wnt/β-catenin signaling due to the reduced expression of Lrp5 and Lrp6. Pretreat...

SnapShot: Noncanonical Wnt Signaling Pathways